• Caspase-3, human recombinant proteinase br The role of AMPK

  2024-07-30

  

  The role of AMPK beyond Caspase-3, human recombinant proteinase homeostasis: regulating metabolism AMPK plays a major role in glucose homeostasis by modulating glucose transport in peripheral tissues [20]. Skeletal muscle, one of the main peripheral tissues involved in glucose uptake and disposa

• Unlike AK inhibition the inhibition of ADA

  2024-07-30

  

  Unlike AK inhibition, the inhibition of ADA activities by EHNA had little effect on spinal reflex potentials, although EHNA did increase extracellular adenosine levels. One explanation for this discrepancy is that the adenosine increase seen herein was not sufficient to inhibit reflex potentials. In

• Here we report discovery of highly selective

  2024-07-30

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of mlkl bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the interaction. To ident

• We next sought to determine the kinase responsible for

  2024-07-30

  

  We next sought to determine the kinase responsible for IR-induced phosphorylation of 53BP1. Because the sites under investigation all lie in a consensus sequence for ATM, ATR and DNA-PK, that are all activated by IR, the involvement of each of these kinases was investigated. Preincubation of lucifer

• GW0742 receptor br Introduction Melatonin N acetyl

  2024-07-30

  

  Introduction Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone which is mainly secreted from the pineal gland. Melatonin is a highly conserved molecule present not only in vertebrates but also in nonvertebrates such as bacteria, protists, fungi, macroalgae, and plants (Cecon et al., 2017

• br Conclusion br Acknowledgements br Introduction

  2024-07-30

  

  Conclusion Acknowledgements Introduction Synapses are the fundamental elements of neuronal networks that enable the processing, encoding, and retrieval of information in the brain, and pathological disruptions in synapse structure are broadly held to underlie the development of neurological

• br Conflicts of interest br

  2024-07-30

  

  Conflicts of interest Financial support This work was supported by grants from the Fondazione Cariplo [Grant number 2011-0463] (Carini); and by Funds for Original Research of the Università del Piemonte Orientale (2016, Project: Carini-Boldorini). The sponsors had no involvement in study desig

• br Declaration of interest br Funding br Introduction The

  2024-07-30

  

  Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers

• It is worth noting that

  2024-07-30

  

  It is worth noting that in S. cerevisiae, the control of two cell-cycle checkpoints requiring Mcm1 involves two very different mechanisms. At the G1/S transition, Mcm1 transactivation activity is inhibited by Yox1 and Yhp1 repressors, whose expression is periodically regulated through the cell cycle

• Several strategies have been employed to design and engineer

  2024-07-30

  

  Several strategies have been employed to design and engineer peptide biosensors of kinase activity, which are quite different from the strategies developed to generate genetically encoded KARs. In all cases, cort g250 induces changes in the spectral properties of the fluorophore(s) incorporated into

• br HIF Blockade in AA

  2024-07-29

  

  HIF-α Blockade in AA Therapy In lieu of the evidence supporting a central role for HIF-α signaling in tumor angiogenesis and CC pathobiology, significant efforts have focused on the discovery of small-molecule HIF-α inhibitors (for exhaustive compendia, see [28,44,45]). In brief, inhibitors vary

• Under some pathological conditions AT R internalization

  2024-07-29

  

  Under some pathological conditions, AT1R internalization is decreased when agonist exposure is prolonged. This weakens or removes the AT1R desensitization effect and leads to AT1R and downstream signal overactivation. AT1R overactivation can result in continued biological effects such as sustained v

• The androgen receptor gene AR is located on

  2024-07-29

  

  The androgen receptor gene (AR) is located on the X-chromosome and consists of eight exons in humans (Brown et al., 1989; Kuiper et al., 1989). The similar gene structure in mice, monotremes and marsupials indicates AR is highly conserved in mammals (Choong et al., 1998; Faber et al., 1991; He et al

• AMP activated protein kinase AMPK

  2024-07-29

  

  AMP-activated protein kinase (AMPK) is a key cellular energy sensor that maintains energy homeostasis at the cellular and whole-organism level (Hardie et al., 2012). Functionally, the AMPK pathway sustains adenosine triphosphate (ATP) production through activation of fatty sch772984 oxidation and a

• ω-Agatoxin TK synthesis Modulating the ability of tumor cell

  2024-07-29

  

  Modulating the ability of tumor ω-Agatoxin TK synthesis to detoxify ROS is a key mechanism by which cysteine metabolism affects tumor cell survival. One study observed hypermethylation of cysteine dioxygenase (CDO1) in 60% of tested breast cancer samples, leading to increased ROS detoxification and

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