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DGK is a key enzyme in glucose uptake
2020-10-15
DGKδ is a key enzyme in glucose uptake in skeletal muscle. Chibalin et al. demonstrated that a decrease in DGKδ expression increases the severity of type 2 diabetes [20]. Additionally, DGKδ expression was increased in people who exhibited enhanced insulin sensitivity after exercise training [56]. Fr
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Hepatic steatosis is strongly associated with insulin resist
2020-10-15
Hepatic steatosis is strongly associated with insulin resistance. Numerous studies in humans and animals have shown that insulin-resistant states are often accompanied by hepatic steatosis (Angulo and Lindor, 2001, Marchesini et al., 1999, Marchesini et al., 2005, Petersen and Shulman, 2006, Seppala
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br Materials and methods br Results br
2020-10-15
Materials and methods Results Discussion Our study assessed the cytokine and chemokine changes associated with first onset PP as compared to HP and HNP groups. In the monocytes/ macrophages/ dendritic N-Acetylneuraminic acid panel, IL-6 levels were found to be significantly elevated in both
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Findings from this study also indicate that
2020-10-15
Findings from this study also indicate that DAPK regulated BimEL expression during OGD as DAPK shRNA transfection inhibited OGD-induced increase of BimEL. A previous study shows that Bim is found in ER compartment in stressed BAY 87-2243 mg but not in normal cells, indicating translocation of Bim d
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Due to the results of the experiment we decided
2020-10-14
Due to the results of the experiment we decided to deploy our cloud service infrastructure with two platform-independent servers instead of one or three. This decision was based on two factors: (a) the use of more than one server is useful to avoid a bottleneck in the system, and (b) using more than
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CD is a key co stimulation surface marker that
2020-10-14
CD28 is a key co-stimulation surface marker that can be detected in all peripheral T Tirofiban hydrochloride monohydrate in newborns, and the proportion of CD28bearing T cells reduces progressively with age [reviewed by (Fagnoni et al., 1996; Weng et al., 2009)]. Therefore, CD28nullCD8+ T cells are
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An interesting observation pertinent to the immunology
2020-10-14
An interesting observation pertinent to the immunology of pregnancy comes from a study by Kruse et al., they found that recurrent miscarriage patients with higher serum progesterone levels had lower Th1/Th2 cytokine ratios suggesting that progesterone levels modulate cytokine production patterns. Pr
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Our previous studies have shown that in a preimplantation
2020-10-14
Our previous studies have shown that in a preimplantation mouse embryo the proportion of inner to outer cells (i.e. precursors of ICM and TE, respectively) is regulated by a different frequency of differentiative cell divisions at the 8- and 16-cell stages. Low number of inner blastomeres generated
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Fluorescein-12-dUTP The ADME profile of AAT was very promisi
2020-10-13
The ADME profile of AAT-008 () was very promising, with high stability in HLM. The pre-clinical pharmacokinetic properties of AAT-008 were also assessed in rats (Sprague-Dawley, male), dogs (beagle, male), and monkeys (cynomolgus, male). The experimentally determined parameters are summarized in .
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Synthesis of and is described in Scheme Compounds and
2020-10-13
Synthesis of 5–7, 12–14, and 18 is described in Scheme 3. Compounds 5–7 and 18 were prepared as outlined in Scheme 3a. Reaction of 4-bromomethylbenzoic product catology (36) with thionyl chloride yielded the corresponding acid chloride, which was converted to the corresponding amide 40a by the usua
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br Materials and methods br Results
2020-10-13
Materials and methods Results We examined the effects of curcumin in Fluo-4 loaded SH-EP1 cdk1 stably transfected with human α7-nACh receptor. Application of curcumin alone in the concentrations up to 100 μM for 30 sec. did not induce any detectable change in intracellular Ca2+ levels in (n =
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An Ubl modification requires several steps that are catalyze
2020-10-13
An Ubl modification requires several steps that are catalyzed by three enzymes, referred to as E1 (activating enzyme), E2 (conjugation enzyme), and E3 (ligase). The SUMO E1 is a heterodimer of SAE1 and Uba2 (also known as SAE2). In brief, an Ubl is first activated by E1 through ATP hydrolysis and fo
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In addition to providing substantial
2020-10-13
In addition to providing substantial insight into substrate recognition, structural studies have revealed important details about mechanisms of glycosylation and HCF-1 cleavage [28,30,33]. Activation of the nucleotide-sugar is accomplished through interactions of the β-phosphate with the N-terminus
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br Materials and methods br Results br Discussion
2020-10-13
Materials and methods Results Discussion Oxidative stress is a disturbance in the balance of pro- and antioxidant species, resulting in oxidative damage to membrane proteins, lipids, and DNA. Oxidative stress is a predisposing factor for the progression of metabolic diseases and liver injur
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The AURA trial was a phase I II study
2020-10-13
The AURA trial was a phase I/II study evaluating the safety, tolerability and activity of Osimertinib in patients with EGFR-mutated NSCLC progressing after a previous EGFR TKI. The phase I component of the study included a dose escalation part (Osimertinib 20mg to 240mg), using a rolling six design,
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