• Glutamate activates cationic glutamate gated channels i e

  2021-09-16

  

  Glutamate activates cationic glutamate-gated channels (i.e. ionotropic glutamate receptors) that mediate the fast excitatory actions of glutamate. It also activate G protein-coupled receptors, named metabotropic glutamate receptors (mGluRs) (Pin and Bettler, 2016). The eight subtypes of mGluRs are k

• br Results and discussion br Conclusion In conclusion our

  2021-09-16

  

  Results and discussion Conclusion In conclusion, our present results indicated that l-glutamate treatment could induce resistant to B. cinerea in postharvest tomatoes. The control effect was probably associated with up-regulating the glutamate receptor-like genes, PR genes and the accumulation

• dna methyltransferase In conclusion we demonstrated that

  2021-09-16

  

  In conclusion, we demonstrated that extrasynaptic glutamate could in situ affect the AA metabolism via brain CYPs. CYP1B1 and CYP2U1 genes in the astrocytes are the downstream genes of CREB, and the up-regulation of CYP1B1 and CYP2U1 expression by glutamate was due to the increases in phosphorylated

• Here we reported series of carbohydrate

  2021-09-16

  

  Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of pd0332991 and their polyol structures give them many unique biological properties as we have described earlier. More inter

• br Acknowledgements The authors are grateful for funding

  2021-09-16

  

  Acknowledgements The authors are grateful for funding provided by the Health Research Council of New Zealand. Introduction Glucose is the most important energy carrier of the brain. Glucose transporter type 1 (Glut1) is located at the blood–brain barrier and assures the energy-independent, fa

• Introduction Human pathogenic Leishmania protozoa comprise d

  2021-09-16

  

  Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio

• br Materials and methods br Results br Discussion Ajuba was

  2021-09-16

  

  Materials and methods Results Discussion Ajuba was originally identified as an adaptor protein which communicates cell adhesive events with nuclear responses to remodel the epithelium (Langer et al., 2008; Marie et al., 2003). Recently, increasing evidence has shown that Ajuba functions as

• The findings in mice were echoed in

  2021-09-16

  

  The findings in mice were echoed in the human studies, in which the effects of higher doses of LY3298178 caused greater weight loss than the selective GLP-1RA dulaglutide. In patients with T2DM, LY3298176 demonstrated meaningful weight loss after only four weeks of treatment. This was consistent wit

• Moreover intestinal chronic inflammation is a

  2021-09-15

  

  Moreover, intestinal chronic inflammation is a promoting factor in the development of CRC in patients affected by inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. We have previously shown that pharmacological FXR activation via its ligand obeticolic ITD 1 counteract

• The primary cancer lesion was

  2021-09-15

  

  The primary cancer lesion was mostly in the uterus and adnexa, followed by the gastrointestinal tract, brain, blood, and kidney and CMK (Fig. 2A). Histopathological findings indicated that most cancers were adenocarcinomas, followed by squamous cell carcinomas, glioblastomas, malignant lymphomas, an

• Enhancer of zeste homolog EZH which functions as

  2021-09-15

  

  Enhancer of zeste homolog 2 (EZH2), which functions as a methyltransferase, is a critical subunit of polycomb repressive complex 2 (PRC2), which has been demonstrated to be involved in the development of the Benzethonium Chloride [23]. Aberrant expression of EZH2 has been found to be associated wit

• A large body of literature have

  2021-09-15

  

  A large body of literature have reported that various cellular pathways are dysregulated in NPC [19]. Among these pathways, Akt is frequently hyperactivated in NPC and regulates diverse cellular processes including tumor cell growth, proliferation, metabolism, survival and invasion, as well as angio

• br Materials and methods br Results br Discussion In

  2021-09-15

  

  Materials and methods Results Discussion In the absence of vascularization phenomena, endothelial cells (ECs) are among the most quiescent cells of the body [27]. ECs proliferation is significant during embryogenesis, as the vasculature is being formed, while in the adult life takes place o

• ghrelin receptor antagonist br Acknowledgement The authors w

  2021-09-15

  

  Acknowledgement The authors would like to thank the University of Johannesburg and the National Research Foundation for the financial support. Mr. D Harris and Dr. R Meyer from Shimadzu South Africa are thanked for their technical support. Prof Ian Dubery is thanked for access to the LC-MS instru

• br Histamine and glycaemia Histamine

  2021-09-15

  

  Histamine and glycaemia Histamine is involved in a wide variety of pathophysiological events mostly related to the inflammatory response through four receptors, namely H1-4Rs. The first studies of (±)-J 113397 and diabetes date back to the 1950s. Since that time the involvement of histamine in d

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