• br Summary br Conflict of interest br Acknowledgments This s

  2021-11-03

  

  Summary Conflict of interest Acknowledgments This study was supported by Grant No. 2014/13/B/NZ7/02277 from the National Science Centre, Poland. Introduction Progesterone (P) is an anticonvulsant hormone (Backstrom et al., 1984, Herzog, 1995, Herzog, 1999, Frye et al., 2000, Reddy, 2002

• br Material and methods br Results br Discussion In

  2021-11-03

  

  Material and methods Results Discussion In the present study, we attempted to unravel the mechanism underlying the statin-mediated inhibition of FGFR3 signaling in chondrocytes, reported earlier by Yamashita and colleagues. We evaluated the role of statins in four different experimental sys

• Regulation of FGF signalling is critical

  2021-11-03

  

  Regulation of FGF signalling is critical to ensure a balanced response to receptor stimulation. This occurs largely through negative feedback mechanisms, including receptor internalisation via ubiquitination (Wang et al., 2002) and induction of negative regulators, for example SPRY, SPRED 1 and 2 an

• br Materials and methods br Results br Discussion This

  2021-11-02

  

  Materials and methods Results Discussion This was the first large study to quantify both total HIV DNA and integrated HIV DNA, which is the main persistent form of HIV [25,26], in samples collected during PHI, chronic infection, and at various time points until the AIDS stage, which was mad

• br Materials and methods br Results

  2021-11-02

  

  Materials and methods Results Discussion It was previously shown that heterologous DNA vaccines composed of fused cDNA fragments encoding chimeric NH2-terminal human HER2 and COOH-terminal rat neu sequences stimulated stronger antibody responses and protective antitumor immunity than either

• br The value of a model of the complex

  2021-11-02

  

  The value of a model of the complex forensic science matrix There have been various models proposed to address the complexity inherent to forensic reconstruction [15], [16], [17]. It is possible to argue that embracing the value of holistic models is important if we are to reclaim the ‘endeavour

• Historically pharmacological investigations have been carrie

  2021-11-02

  

  Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery

• br Mutagenesis and Receptor Modeling Studies br Signal

  2021-11-02

  

  Mutagenesis and Receptor-Modeling Studies Signal Transduction and Receptor Desensitization Therapeutic Potential of HCA Receptor Ligands Although all members of the HCA receptor family are potentially interesting drug targets, only HCA2 is currently exploited as such. Therefore, this sectio

• Finally we investigated increasing basicity as a way to impr

  2021-11-02

  

  Finally, we investigated increasing basicity as a way to improve solubility. We expected that conversion of the ether linkage of to an -methyl group could improve solubility. More than expected, px express demonstrated significant improvement of values of solubility for the two media, especially for

• br Materials and methods br Results br Discussion DNA repair

  2021-11-02

  

  Materials and methods Results Discussion DNA repair pathways have evolved for a long time to act independently of one another. However, over the past decade several overlaps and crosstalks between these pathways were identified, showing that the DNA repair system is more complex than previo

• br Results and discussion br Conclusions TZDs represent

  2021-11-02

  

  Results and discussion Conclusions TZDs represent a well-studied group of antidiabetic agents. Based on previous observations of the ability of some TZDs to activate FFAR1, we designed five scaffolds consisting of the TZD head, a linker, and a carefully selected privileged structure. For the p

• With the advent of genome

  2021-11-02

  

  With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the

• br Methods br Results br Discussion Among three

  2021-11-02

  

  Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zinc

• Work in the Ruiz i Altaba lab was

  2021-11-02

  

  Work in the Ruiz i Altaba lab was funded by grants from the Swiss National Science Foundation, the Ligue Suisse Contre le Cancer, the European FP7 Marie-Curie Initial Training Network HEALING, a James McDonnell Foundation 21st Century Science Initiative in Brain Cancer-Research Award and funds from

• In the small intestine digestion and absorption of the

  2021-11-02

  

  In the small intestine, digestion and bax pathway of the nutrients are the next processes with an impact on the resulting plasma profile. Normally, neither carbohydrate digestion nor absorption are limiting factors, which is illustrated by the rapid and extensive absorption of glucose in conditions

15650 records 557/1044 page Previous Next First page 上5页 556557558559560 下5页 Last page