• A role for YAP in mediating resistance to EGFR inhibition

  2022-11-16

  

  A role for YAP in mediating resistance to EGFR inhibition has also been described [28], [29]. In line with these evidences, we observed increased YAP activation in all the generated EGFR TKI–resistant cells, testified by decreased phosphorylation on the inhibitory serine 127, enhanced nuclear locali

• A role for YAP in mediating resistance to EGFR inhibition

  2022-11-16

  

  A role for YAP in mediating resistance to EGFR inhibition has also been described [28], [29]. In line with these evidences, we observed increased YAP activation in all the generated EGFR TKI–resistant cells, testified by decreased phosphorylation on the inhibitory serine 127, enhanced nuclear locali

• br Ataxia telangiectasia and Rad related

  2022-11-14

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• br Dysregulated aromatase expression the link between

  2022-11-14

  

  Dysregulated aromatase expression: the link between obesity and breast cancer Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, influencing the local production and bioavailability of estrogens (Morris et al, 2011, Subbaramaiah et al, 2012). Bowers

• The lack of benefit in terms of overall survival

  2022-11-14

  

  The lack of benefit in terms of overall survival for antiangiogenic treatment was similar when antiangiogenic drug was used both as first and second-line therapy, and both in association with cytotoxic treatment or alone. Noteworthy, a trend for an inferior outcome was observed in the group of patie

• Similar studies in Swedish Mutation of

  2022-11-11

  

  Similar studies in Swedish Mutation of APP AD transgenic mice revealed reduced dynamin 1, AP180, and synaptophysin expression in the hippocampus, particularly prominent in the CA1 and CA4 subfields [19]. These findings imply that Aβ can act not only as a modulator of exocytosis but is a potent regul

• br Mechanisms for regulation of intracellular cholesterol ho

  2022-11-10

  

  Mechanisms for regulation of intracellular cholesterol homeostasis Cells maintain intracellular free cholesterol levels and distribution within stringent tolerances by several mechanisms [55]: (1) uptake of native LDL (the major extracellular carrier of cholesterol) by LDL receptors and modified

• br Mechanisms for regulation of intracellular cholesterol ho

  2022-11-10

  

  Mechanisms for regulation of intracellular cholesterol homeostasis Cells maintain intracellular free cholesterol levels and distribution within stringent tolerances by several mechanisms [55]: (1) uptake of native LDL (the major extracellular carrier of cholesterol) by LDL receptors and modified

• Moreover an increase of extracellular calcium stimulates BMP

  2022-11-09

  

  Moreover, an increase of extracellular calcium stimulates BMP-2 expression of pulp Z-Ligustilide synthesis via L-type calcium channel and ERK signaling, which can be attenuated by PD98059 and nifedipine . Dental pulp cells expressed little calcium-sensing receptors . immunohistochemistry staining

• caudatin The results also showed that

  2022-11-09

  

  The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 caudatin stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transection models (Ga

• Tension within the network could be explained by

  2022-11-09

  

  Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling IL-10, human recombinant protein australia filaments towards each other [10]; or contractility that is caused by disassembly of a crosslin

• Given the profound expression of HT A

  2022-11-09

  

  Given the profound Tranexamic Acid australia of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes a

• br Acknowledgements Authors wish to thank Sabanci University

  2022-11-09

  

  Acknowledgements Authors wish to thank Sabanci University (Turkey), Tubitak (Cost Eu-Ros, 113Z463), and the University of Turin (Italy) for supporting this work. Beyza Vurusaner is supported by Sabanci University Post-doctoral research scholarship. Introduction Endometriosis is defined as the

• Imatinib is a well known anticancer drug

  2022-11-09

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing rna polymerase ii (K56

• We also measured macrophage infiltration and CLS

  2022-11-09

  

  We also measured macrophage infiltration and CLS presence in peri-gonadal AT from db/db mice and controls. CLS are morphological features within AT that are accurate indicators of adipocyte death and macrophage infiltration [56]. An earlier study showed that CLS macrophages account for >90% of the t

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