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Based on the improved characteristics of the mutant ECDs
2025-01-21
Based on the improved characteristics of the mutant ECDs we proceeded to crystallization trials, starting with the β1-BPloop as the most promising. We obtained rod shaped hexagonal crystals reproducibly, but with moderate diffraction ability (Fig. 5). Furthermore, the crystals were sensitive in moun
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br Materials and methods br Functional demonstrations of ACh
2025-01-21
Materials and methods Functional demonstrations of ACh/GABA cotransmission The cotransmission of GABA and ACh has been best characterized in starburst amacrine cells (SACs) of the retina. SACs are a subtype of amacrine cell, a diverse set of retinal interneurons that are crucial for processing
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Our analysis has devoted limited attention to the standard
2025-01-21
Our analysis has devoted limited attention to the standard corporate tax scheme with deductibility for interest payments that is in place in most countries. A conventional corporate tax scheme offers partial deduction of capital costs, and can be interpreted as a change in the degree of capital cost
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Acknowledgments br Introduction Prostate cancer
2025-01-21
Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi
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BMS 299897 Assessment of antibiotic appropriateness is recei
2025-01-20
Assessment of antibiotic appropriateness is receiving increased attention in the face of growing concerns about the emergence of MDROs, as well as the rise in adverse outcomes associated with antibiotic use such as C. difficile infection. In this study, 15% of cultured Gram-negative organisms met th
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Long term blood pressure regulation is linked
2025-01-20
Long term blood pressure regulation is linked to renal function through the mechanisms of pressure natriuresis (Evans et al., 2005), which has been shown to be modulated by the RAS (Hall et al., 1999). Key components of the RAS are expressed throughout the kidney, and are implicated in renal excreto
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The RE compartment has been shown to
2025-01-20
The RE compartment has been shown to be critical for supplying AMPAR during LTP (Hanley, 2010; Park et al., 2004), but whether they also supply AMPAR for synaptic scaling has been less clear (Gainey et al., 2015; Tan et al., 2015). Interestingly, although an increase in μ3A is necessary for scaling,
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br Funding br Introduction Plants
2025-01-20
Funding Introduction Plants absorb both inorganic nitrogen (ammonium and nitrate) and organic nitrogen (amino acids and peptides) from the soil [1]. The first organic nitrogenous molecule produced from inorganic nitrogen is Gln, whose terminal amino group is successively transferred to make Gl
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The G R mutation is located
2025-01-20
The G1202R mutation is located at the solvent front of the ALK kinase domain adjacent to the inhibitor's binding pocket. Although barely reported in the setting of crizotinib resistance, it has emerged as the most refractory mutation to both the first- and second-generation ALK inhibitors. The large
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br Acknowledgements This work was supported by grants from t
2025-01-20
Acknowledgements This work was supported by grants from the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (973) (Grant No.: 2013CB733602), the Major Research Plan of the National Natural Science Foundation of C
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Since the localization of LO depends
2025-01-18
Since the localization of 5-LO depends on phosphorylation, we also analyzed the phosphorylation profile of 5-LO-WT and all isoforms by Western blot using specific Bufalin against the phosphorylation sites S271 and S523. Whereas phosphorylation at S271 activates the 5-LO, inhibits nuclear export and
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The observation that vortioxetine blocks HT induced currents
2025-01-18
The observation that vortioxetine blocks 5-HT-induced currents in 5-HT3 receptor-expressing oocytes suggests that vortioxetine acts to functionally antagonize these receptors, and is in line with previously published data (Bang-Andersen et al., 2011). For example, Mørk et al. (2012) demonstrated tha
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If the lack of specificity and
2025-01-18
If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it erk pathway may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as limi
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We used the lead compound C to demonstrate
2025-01-18
We used the lead compound C4 to demonstrate that small molecule ACL inhibitors can recapitulate ACL knockdown (KD) in modulation of cancer stemness. We have shown previously that ACL KD reduced the CSC population in multiple cancer cell lines. The E-snail cells are an established CSC model system.
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The reproducibility of the IC measurements in the Pf
2025-01-18
The reproducibility of the IC50 measurements in the Pf-dhfr yeast was far better than comparable measurements in P. falciparum in vitro [1]. This is probably due to the extremely low level of folate and para-aminobenzoic triclosan products in the yeast growth medium. This is in contrast to culture o
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