• Filipin III: Advanced Probe for Membrane Cholesterol Dyna...

  2025-09-28

  Discover how Filipin III, a cholesterol-binding fluorescent antibiotic, is revolutionizing the quantitative and spatiotemporal analysis of membrane cholesterol dynamics. This article provides a unique perspective on Filipin III’s mechanistic specificity, live-cell applications, and emerging role in unraveling cholesterol homeostasis in metabolic disease.

• DAPI (hydrochloride): Transforming DNA Visualization in O...

  2025-09-27

  Explore how DAPI (hydrochloride), a fluorescent DNA-specific probe, revolutionizes quality control in organoid biomanufacturing by enabling robust, high-content DNA visualization and cell cycle analysis. Discover advanced methodologies beyond conventional cell fate mapping.

• Filipin III: Illuminating Cholesterol Dynamics in Membran...

  2025-09-26

  Explore how Filipin III, a cholesterol-binding fluorescent antibiotic, uniquely enables quantitative and spatial analysis of cholesterol in membrane microdomains. This article offers advanced mechanistic insight and addresses emerging challenges in cholesterol-related membrane studies.

• Biotin (Vitamin B7): Molecular Insights and Next-Gen Rese...

  2025-09-25

  Explore the advanced molecular roles of Biotin (Vitamin B7, Vitamin H) as a water-soluble B-vitamin and biotin labeling reagent in metabolic and motor protein research. This article uniquely dissects its mechanistic impact on protein regulation and offers new perspectives for experimental design.

• Berberine (CAS 2086-83-1): Beyond Metabolism—A Systems Bi...

  2025-09-24

  Explore how Berberine (CAS 2086-83-1), a potent isoquinoline alkaloid and AMPK activator, orchestrates metabolic regulation and inflammation at the systems level. This in-depth article uniquely integrates advanced molecular insights with translational applications for metabolic and inflammatory disease research.

• L1023 Anti-Cancer Compound Library: Accelerating Small Mo...

  2025-09-23

  Explore how the L1023 Anti-Cancer Compound Library streamlines high-throughput screening of anti-cancer agents and enables discovery of novel molecular targets such as PLAC1 in cancer research.

• Imatinib is a well known anticancer

  2025-04-22

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing Sulfo-NHS-Biotin (K562

• Fencilli et al reported derivatives of PHA which demonstrate

  2025-04-21

  

  Fencilli et al. reported derivatives of PHA-680626 (15) which demonstrated strong anti-proliferative activity against large group of leukaemia cell lines including IM-resistant BAF3 cells expressing mutants like T315I, M351T and E255K. Decrease in Histone H3 phosphorylation led to induction of endo-

• A unique finding in this study is that

  2025-04-18

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic Y-27632 dihydrochloride for substrate, can regulate CREB phosphoryation in the context o

• Receptor Subtypes and Their Function Critical Appraisal Larg

  2025-04-16

  

  Receptor Subtypes and Their Function – Critical Appraisal Largely unselective ligands of the benzodiazepine binding site, such as diazepam, are known to elicit a wide range of in vivo effects including hypnosis, sedation, anxiolysis, and muscle relaxation. Genetically modified mice were introduced

• However most of these SBVS studies were focused on the

  2025-04-16

  

  However, most of these SBVS studies were focused on the target(s) for which crystal structures were available or have a similar template in PDB for comparative modeling. Besides, these were limited to SBVS only which relies on the rigid binding pocket, therefore, it may result in high false positive

• Several structural classes of ASK

  2025-04-15

  

  Several structural HotStart™ 2X Green qPCR Master Mix of ASK1 inhibitors, mostly from industry but also from academia, have been identified over the last decade. In 2012, Terao et al. (Takeda) reported imidazo[1,2-α]pyridine () as a potent ASK1 inhibitor derived from structure-based drug design. GSK

• In the current study SA was assessed

  2025-04-12

  

  In the current study, SA was assessed to confirm the safety of CS addition to erythrocytes SA as well as SA elicits antioxidant action. It has been reported that, ROS induced desialylation by depletion of SA content from cell surfaces (Pawluczyk et al., 2014, Harisa, 2015). Therefore, significant de

• The reduction of heterodimerization of KOR and APJ by both

  2025-04-10

  

  The reduction of heterodimerization of KOR and APJ by both doses of apelin found in the present study may result in inducing protective effects of apelin on the myocardium imposed to high pressure in renovascular hypertension conditions. The finding that apelin in both doses reduced heterodimerizati

• On the other hand our study permits to draw general

  2025-04-09

  

  On the other hand, our study permits to draw general conclusions about the complex functional pattern of C4HT, C8HT and C12HT, in comparison with the parent molecule HT and two reference compounds like Trolox and vitamin E. Table 1 summarizes the results obtained in the present investigation (for th

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