• br Conclusion br Conflicts of interest br

  2024-04-01

  

  Conclusion Conflicts of interest Introduction Enzymes are widely applied as biocatalysts in fields such as synthetic chemistry [1], pharmaceuticals [2], environmental treatment [3], and food technology [4] because they can catalyze chemical transformations in a highly selective manner under

• br Material and methods br Results br Discussion Clinical ge

  2024-04-01

  

  Material and methods Results Discussion Clinical gene therapy trials with viral vectors have been in use for treatment of various genetic disorders and diseases, however efficacious, targetable and highly reliable non-viral delivery systems are needed for safe and long-term applications. De

• Inhibitors of mPGES are considered as safe alternative to

  2024-04-01

  

  Inhibitors of mPGES-1 are considered as safe alternative to NSAIDs in the treatment of chronic inflammatory diseases that are characterized by excessive PGE2 production (Bahia et al., 2014; Khurana and Jachak, 2016; Koeberle et al., 2016; Korotkova and Jakobsson, 2014; Norberg et al., 2013; Psarra e

• br Acknowledgements We thank Dr Stefan Schulte

  2024-04-01

  

  Acknowledgements We thank Dr. Stefan Schulte-Merker and his group members at the Hubrecht Institute (Utrecht, the Netherlands) for their invaluable support of the zebrafish studies. Our work is supported by grants from the Dutch Cancer Society (KWF) and the Netherlands Organisation for Scientific

• br Viral manipulation of host factors to

  2024-04-01

  

  Viral manipulation of host factors to oppose anti-viral autophagy To escape or manipulate autophagy, some viruses developed strategies that are based on the recruitment of host-cell endogenous factors. The non-enveloped double-stranded DNA virus adenovirus is rapidly endocytosed after attachment.

• The acidification of endocytic compartments is closely

  2024-04-01

  

  The acidification of endocytic compartments is closely related to endocytic activity, although the mechanism linking acidification and membrane dynamics is largely unknown. In a recent RNA interference (RNAi)-based screen, V-ATPase depletion blocked the formation of clathrin-coated vesicles, an effe

• CK is considered a central controller of cellular energy hom

  2024-04-01

  

  CK is considered a central controller of cellular energy homeostasis that catalyzes the reversible transfer of a phosphoryl group from ATP to adenosine diphosphate (ADP) and creatine to produce PCr [5]. This enzyme builds up a large pool of rapidly diffusing PCr for temporal and spatial buffering of

• br Crystal structure ACLY protein is a homotetramer of four

  2024-04-01

  

  Crystal structure ACLY protein is a homotetramer of four identical subunits [9]. Each polypeptide chain contains 1101 amino-acid residues [10]. The crystal structure of full-length ACLY protein is yet unresolved. However, Sun et al. recently succeeded in crystallizing chymotrypsin-truncated human

• PF-562271 australia ASK has been identified as

  2024-04-01

  

  ASK2 has been identified as an ASK1 binding protein (Wang et al., 1998). ASK1 supports the stability and active configuration of ASK2 in the heteromeric complex, while ASK2 has been found to activate ASK1 by direct phosphorylation (Takeda et al., 2007). Unlike ASK1, which is ubiquitously expressed i

• br In vivo visualization of aromatase with positron

  2024-04-01

  

  In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high (+)-Aphidicolin photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the living b

• br Introduction Humans have consumed mushrooms for centuries

  2024-03-30

  

  Introduction Humans have consumed mushrooms for centuries because of their high nutrient content and low lipid content, as well as their excellent flavor and texture [1]. Edible mushrooms possess notable medicinal properties and bioactivities, including antitumor, antiviral, antidiabetic, and ant

• Ampicillin Trihydrate br Eprosartan The AT R antagonist epro

  2024-03-30

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Ampicillin Trihydrate and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular

• In our sequential model for tau and A

  2024-03-30

  

  In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal Doxofylline in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in their

• br Disclosure br Acknowledgments br Introduction Anaplastic

  2024-03-30

  

  Disclosure Acknowledgments Introduction Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, belongs to the insulin receptor kinase subfamily [1]. Oncogenic activation of ALK is associated with the BRD-6125 synthesis and progression of multiple human cancer types [2,3], including

• BX-912 Cancers that responded to immune

  2024-03-30

  

  Cancers that responded to immune checkpoint inhibitors were shown to present a type I interferon (IFN) signature in the TME 33, 34. Type I IFNs positively regulate the expression of tumor antigens and their crosspresentation by DCs to tumoricidal CTLs. Furthermore, CD8+ T cell develops full effector

15597 records 155/1040 page Previous Next First page 上5页 151152153154155 下5页 Last page