• In contrast to adults PBL in children

  2019-04-25

  

  In trifluoperazine hydrochloride to adults, PBL in children is regarded as a clinical entity that is distinct from its adult counterpart. Like many other pediatric malignancies, PBL is considered a systemic disease in children. In small retrospective studies, PBL in children is characterized by rapi

• br Acknowledgments The authors would like to thank Sarah

  2019-04-25

  

  Acknowledgments The authors would like to thank Sarah Mack for technical assistance with the histology and IHC. We would also like to acknowledge Dr. Gregory Dieudonne in the Department of Musculoskeletal Radiology, University of Rochester Medical Center for advice and assistance in manuscript wr

• br Primary biliary cholangitis Primary biliary

  2019-04-25

  

  Primary biliary cholangitis Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is another rare but devastating immune-mediated cholangiopathy. Similar to PSC, PBC is characterized by portal inflammation leading to fibrosis and eventually cirrhosis. Distinct from PSC

• Bile acids are cholesterol derivatives

  2019-04-25

  

  Bile acids are cholesterol derivatives produced only in the hepatocytes of the liver. Hepatic bile acid synthesis represents the only quantitatively significant route for cholesterol elimination. Bile acids are amphipathic physiological detergents that facilitate dietary cholesterol, lipid and fat-s

• We modelled how the loss of health

  2019-04-25

  

  We modelled how the loss of health-care workers—defined here as doctors, nurses, and midwives—to Ebola might affect maternal, infant, and under-5 mortality in Guinea, Liberia, and Sierra Leone, with the aim of characterising the order of magnitude of likely effects, not providing specific prediction

• Development of an atrial esophageal fistula is one of

  2019-04-24

  

  Development of an atrial–esophageal fistula is one of the most dreaded complications of AF ablation [78]. A relatively large-scale nonrandomized study revealed that the anatomical risk factor of a small LA-to-esophageal distance was the most important factor in esophageal ulceration when using an ir

• br Material and Methods br Results br Discussion Radiofreque

  2019-04-24

  

  Material and Methods Results Discussion Radiofrequency ablation has a long history of use. It has been used especially in the neurosurgical field [8,9]. Rosenthal described the first ablations in bone 20 years ago [5]. Technically the radiofrequency generator forms an electric current leadi

• The pathophysiology underlying ONJ is unclear Decreased bone

  2019-04-24

  

  The pathophysiology underlying ONJ is unclear. Decreased bone remodeling induced by bisphosphonates or inhibition of osteoclast function, which interferes with healing of the microfractures and trauma occurring after dental extraction, have been hypothesized as potential mechanisms for ONJ, but thes

• br VIII Si atendemos a que Pablo del Prado en

  2019-04-24

  

  VIII. Si atendemos phosphodiesterase inhibitors que Pablo del Prado en su Directorio espiritual, todavía en el año de 1650, incorporaba numerosas oraciones para la comunión espiritual indígena, junto a recomendaciones sobre la exclusión de la efectiva, no parece probable que se alcanzara nunca un

• An interphase FISH analysis with BCR ABL DCDF dual

  2019-04-24

  

  An interphase FISH analysis with BCR-ABL1-DCDF (dual colour dual fusion) probes (Abbott) showed a normal signal pattern. In addition, an RT-PCR screen with primers specific for the BCR-ABL1 p210 and p190 fusion transcripts and a JAK2V617F mutation analysis were both negative. Chromosomal analysis of

• In the days before Christmas

  2019-04-23

  

  In the days before Christmas, 1952, adverse weather conditions and the burning of sulphurous coal led to the death of almost 12 000 people in London. Despite improvements in pollution prevention since the “Great Smog”, London continues to experience toxic air pollution linked to thousands of prematu

• A major development during was that

  2019-04-23

  

  A major development during 2015 was that OCV demand exceeded supply (). The main reasons for this increase in demand are the observed feasibility of mass OCV campaigns and their ability to confer protection to underserved populations in complex situations. The increased availability and use of OCV h

• br Conflict of interest br Introduction br

  2019-04-23

  

  Conflict of interest Introduction Case report Discussion Dextrocardia is commonly associated with situs inversus totalis (incidence: 2 in 10,000 individuals) and rarely associated with situs solitus (incidence: 1 in 20,000 individuals). While associated cardiac anomalies are seen in appr

• More recently primary tumor driven generation of a bone

  2019-04-23

  

  More recently, primary tumor driven generation of a bone pre-metastatic niche was observed in a mouse model of estrogen receptor-negative breast cancer metastasis. Specifically, lysyl oxidase (LOX) secreted into the circulation from hypoxic primary breast tumors disrupted bone homeostasis, thereby i

• br Autophagy and lipid metabolism LD formation is an

  2019-04-23

  

  Autophagy and lipid metabolism LD formation is an indispensable step in lipid metabolism. The Atg8/LC3 conjugation system is essential for autophagosome membrane formation. However, some evidence suggests that Atg8/LC3 conjugation is also involved in LD formation. Indeed, LD formation is suppress

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